Tinnitus

Tinnitus is the perception of noise and/or ringing in the ears, when no external sound is present, caused by a symptom of an underlying condition.

  • What is Tinnitus?
  • Tinnitus & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Tinnitus?

Definition
Tinnitus is the perception of noise and/or ringing in the ears, when no external sound is present, caused by a symptom of an underlying condition. Tinnitus can be improved with treatment and is typically not a sign of any severe health issues.

Symptoms
People with tinnitus can experience these types of phantom noises in the ears:

  • Buzzing
  • Roaring
  • Clicking
  • Hissing
  • Humming

Tinnitus can vary in volume and frequency and depending on the severity it may interfere with the ability to concentrate or hear external sound(s).

Cause
There are two existing types of Tinnitus:

  • Subjective tinnitus Only patients can hear it. The cause of this type of tinnitus could be due to the problems in the outer, middle, or inner ear and problems with the auditory nerves. Another reason for this type of tinnitus could be that a part of the brain interprets nerve signals as sound.
  • Objective tinnitus
    Doctors can hear it when they examine patients. It is an uncommon type of tinnitus and this could be due to blood vessel problems, middle ear bone condition, or muscle contractions.

The symptoms are often caused by an ear injury, age-related hearing loss, ear hair cell damage, and/or a circulatory system disorder. However, other ear problems, chronic health conditions, ear injuries, or conditions affecting the nerves in the ear or the brain’s hearing center may cause tinnitus as well.1

  • Cannabinoids
  • Cannabinoids receptors
  • Endocannabinoids
  • CBD
  • THC
  • CB1
  • 2AG
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Tinnitus
& cannabinoids

Tinnitus Graphic

Preclinical data proposes that THC and CBD may be used in the therapeutic treatment of tinnitus, as the endocannabinoid system can be involved in the development of tinnitus via the cannabinoid receptor CB1 and the endocannabinoid 2AG.
THC and CBD can help regulate tinnitus symptoms but to this date, the specific mechanism of cannabinoids remains to be elucidated. 2

Note: If you have any further information relevant to the connection between Tinnitus and cannabinoids, or find any of the information inaccurate, outdated or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

CB1 receptors and 2AG are present in the auditory brainstem (Zhao et al., 2009).

The endocannabinoid system may be involved in multisensory integration in the brain (Zhao et al., 2011).

In rats, a decreased number of CB1 receptors in the ventral cochlear nucleus could be associated with tinnitus development (Zheng et al., 2007).

It is proposed that tinnitus is a form of sensory epilepsy and that cannabinoid receptor agonists may exhibit anti-epileptic activities (Smith and Zheng, 2015).

References
Clinical trials

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