Stroke

A stroke is a serious medical condition which happens when the blood supply to some part of the brain is abruptly interrupted or decreased, leading to a sudden death of brain cells

  • What is a Stroke?
  • Stroke & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Stroke?

Definition
A stroke is a serious medical condition that happens when the blood supply to some part of the brain is abruptly interrupted or decreased, leading to sudden death (within minutes) of brain cells.1

Symptoms

  • Difficulty speaking, communication, and understanding other people
  • Sudden paralysis, numbness, or weakness in the face, arm, or leg
  • Eye problem(s) e.g. blurred-, blackened- or double vision
  • Sudden and severe headache, that may be accompanied by purging, dizziness, or distorted consciousness
  • Difficulty walking e.g. lack of balance or stumbling

It is important to be aware of when the first symptoms of stroke occur because the treatment success depends on how fast patients get help.

Cause
There are several types of strokes with ischemic stroke being the most common.

  • Ischemic stroke
    This occurs when the brain´s blood vessels are narrowed or blocked, leading to decreased blood flow.
  • Hemorrhagic stroke
    This occurs when a blood vessel in the brain leaks or bursts.
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • CBD
  • THC
  • 5-HT1A
  • CB1
  • CB2
  • PPARα
  • Anandamide
  • OEA
  • PEA
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites
  • Caryophyllene
  • Myrcene

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Stroke
& cannabinoids

Heart Stroke Xray

Clinical research proposes that the cannabinoids THC and CBD may be helpful in the treatment of stroke as these cannabinoids have been found to exhibit neuroprotective effects.2
It was shown that cannabinoids can help limit excitotoxicity., oxidative stress. and neuroinflammation, suggesting that they may represent a good pathway when developing future treatments.3

Note: If you have any further information relevant to the connection between Stroke and cannabinoids, or find any of the information inaccurate, outdated or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature Discussion
  • Clinical trials
Clinical trials

Meta-analysis disclosed that neuronal degeneration can be reduced by endocannabinoids such as AEA, OEA, or PEA and plant cannabinoids such as THC and CBD after stroke (England et al., 2015). The strongest protective effect was through activation of CB1 and/or CB2 but other receptors like 5-HT1A and PPARα are also likely to play a role.

References

Want to know more about Stroke?

Then signup our FREE newsletter below