Post-traumatic stress disorder (PTSD) is a mental disorder that is caused by a traumatic event which can lead to various symptoms such as severe anxiety, flashbacks and nightmares.
Definition
Post-traumatic stress disorder (PTSD) is a mental disorder that is caused by a traumatic event which can lead to various symptoms such as severe anxiety, flashbacks, and nightmares. These symptoms may interfere with many aspects of life.1
Symptoms
The occurrence of PTSD symptoms can vary greatly between people. The symptoms sometimes start very quickly after the traumatic event (within four weeks) but in other cases, they may not appear until years after a traumatic experience. However, when the symptoms do appear, they may interfere with daily activities, social interaction, and work. In general, PTSD symptoms can be categorized into four distinct types:1
Cause
Currently, the exact cause of PTSD is not known, however, experienced or witnessed traumatic events such as military service, abuse (violence, sexual, etc.), assault, accidents, and threats can trigger the disorder. People can also be likely to develop PTSD due to genetics (family history, anxiety, depression, or temperament) or how the brain regulates chemicals/hormones in the body.1
Clinical research proposes that the cannabinoids THC and CBD may be beneficial in the treatment of PTSD patients as they may help improve their symptoms.2
In addition, preliminary studies in humans propose that cannabinoids may help reduce and improve several PTSD symptoms such as sleep quality, nightmares, hyperarousal, and prevent the development of PTSD if cannabinoids are administered shortly after a traumatic event.3
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There is a connection between cannabis use and PTSD, suggesting that this may be used as a coping strategy for PTSD (Bonn-Miller, Babson, Vujanovic, & Feldner, 2010; Bonn-Miller, Vujanovic, Feldner, Bernstein, & Zvolensky, 2007; Bujarski et al., 2012; Cougle, Bonn-Miller, Vujanovic, Zvolensky, & Hawkins, 2011; Kevorkian et al., 2015).
In rats, extinction of fear memories was facilitated by CBD, THC and synthetic cannabinoids (Bitencourt, Pamplona, & Takahashi, 2008; Campos, Ferreira, & Guimarães, 2012; Do Monte, Souza, Bitencourt, Kroon, & Takahashi, 2013; Lemos, Resstel, & Guimarães, 2010; Levin et al., 2012; Morena et al., 2018; Resstel, Joca, Moreira, Corrêa, & Guimarães, 2006; Stern et al., 2015).
CBD has demonstrated to produce a positive effect on sleep processes, suggesting that this can be beneficial when targeting sleep disorders connected to PTSD (Chagas et al., 2013; Hsiao, Yi, Li, & Chang, 2012).
In a pilot study, PTSD-related nightmares and other symptoms severity were reduced by THC in patients with PTSD (Roitman, Mechoulam, Cooper-Kazaz, & Shalev, 2014).
In a retrospective study of 80 patients with PTSD, PTSD-related symptoms were reduced by cannabis (Greer, Grob, & Halberstadt, 2014).
Fear extinction was shown to be facilitated by CBD and THC, proposing that cannabinoids may contribute to preventing the recovery of fear (Das et al., 2013; Rabinak et al., 2013). In one open clinical trial, significant relief of PTSD symptoms was provided by cannabis in most patients.
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=481&&search_pattern=posttraumatic