There is a connection between cannabis use and PTSD, suggesting that this may be used as a coping strategy for PTSD (Bonn-Miller, Babson, Vujanovic, & Feldner, 2010; Bonn-Miller, Vujanovic, Feldner, Bernstein, & Zvolensky, 2007; Bujarski et al., 2012; Cougle, Bonn-Miller, Vujanovic, Zvolensky, & Hawkins, 2011; Kevorkian et al., 2015).
In rats, extinction of fear memories was facilitated by CBD, THC and synthetic cannabinoids (Bitencourt, Pamplona, & Takahashi, 2008; Campos, Ferreira, & Guimarães, 2012; Do Monte, Souza, Bitencourt, Kroon, & Takahashi, 2013; Lemos, Resstel, & Guimarães, 2010; Levin et al., 2012; Morena et al., 2018; Resstel, Joca, Moreira, Corrêa, & Guimarães, 2006; Stern et al., 2015).
CBD has demonstrated to produce a positive effect on sleep processes, suggesting that this can be beneficial when targeting sleep disorders connected to PTSD (Chagas et al., 2013; Hsiao, Yi, Li, & Chang, 2012).
In a pilot study, PTSD-related nightmares and other symptoms severity were reduced by THC in patients with PTSD (Roitman, Mechoulam, Cooper-Kazaz, & Shalev, 2014).
In a retrospective study of 80 patients with PTSD, PTSD-related symptoms were reduced by cannabis (Greer, Grob, & Halberstadt, 2014).