Obesity

Obesity is a common and complex disease that leads to excessive amount of body fat. Obesity increases the risk of severe conditions and health problems like diabetes (type 2), high blood pressure, heart disease and certain types of cancer.

  • What is Obesity?
  • Obesity & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Obesity?

Definition
Obesity is a common and complex disease that leads to an excessive amount of body fat. Obesity increases the risk of severe conditions and health problems like diabetes (type 2), high blood pressure, heart disease, and certain types of cancer.1

How to determine and diagnose obesity?
Body mass index (BMI) is often used to diagnose obesity and possibly identify potential risk factors.
Obesity is diagnosed when BMI is 30 or higher and this can be determined by:

BMI= Weight (kg) / Height2 (cm)

However, BMI is not fully adequate as it does not directly measure body fat. Some people like athletes may have high BMI and be incorrectly classified as obese due to the weight of their muscles.1

Harvard School of Public Health has identified 10 methods to measure obesity including BMI. Other methods that can help determine body fat include waist circumference and waist-to-hip ratio in order to provide a prediction of the disease development and death associated with obesity. 2

Symptoms
Day-to-day symptoms of obesity:3

  • Quickly being out of breath
  • Increased sweating
  • Difficulty performing physical activity
  • Pain in joints and back
  • Increased snoring
  • Psychological problems associated with the feeling of isolation and low self-esteem that may affect relationships with family and friends.

Development of conditions due to obesity:4

  • Osteoarthritis
  • Heart disease
  • Stroke
  • Diabetes (type 2)
  • Sleep apnea
  • Fertility problems
  • Gallstones
  • Specific types of cancer
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids
  • CBD
  • THCV
  • CB1
  • GPR119
  • TRPV1
  • PPARα
  • 2AG
  • Anandamide
  • DHEA
  • EPEA
  • OEA
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites
  • Eugenol
  • Limonene

Strains

  • DAGL

Metabolites

The connection between Obesity
& cannabinoids

Obesity Graphic Women

Cannabinoid receptors are involved in regulating food intake and inflammation; therefore, cannabinoids may have a therapeutic potential in the treatment of obesity.5

Additionally, preclinical data proposes that the cannabinoids THCV and CBD may have a beneficial effect on weight loss, suggesting that these cannabinoids may be of interest in treating obesity.6

Note: If you have any further information relevant to the connection between Obesity and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

It was found that the amount of circulating lipids can be reduced by THCV and CBD. Moreover, weight-loss can be stimulated by the same cannabinoids (Silvestri et al., 2015).

Low doses of THCV (from 3mg/kg) stimulated hypophagia and reduction in body weight, proposing that THCV may be used in treating obesity and metabolic syndrome. These effects can be removed when combining THC with THCV, but they can be reversed when combining them with CBD (Riedel et al., 2009; Silvestri et al., 2015; Wargent et al., 2013).

In contrast to THCV, Rimonabant (anorectic anti-obesity drug) exhibited anxiogenic activities. This could due to THCV acting as a neutral CB1 receptor antagonist while Rimonabant functions as an inverse agonist (O’Brien et al., 2013).

References
Clinical trials

Many clinical trials aimed to show that synthetic cannabinoids can help reduce body intake by blocking CB1.

Although significant weight loss was caused by these synthetic cannabinoids, these clinical trials were left behind because these cannabinoids produced excessive adverse reactions such as depression, vertigo, heart problems, etc. (Bergholm et al., 2013; Kipnes et al., 2010; Motaghedi et al., 2011).

References

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