Morphine interaction

Morphine is an opioid drug used as a strong painkiller to treat severe pain by blocking pain signals from travelling along the nerves to the brain.

  • What is Morphine Interaction?
  • Morphine Interaction & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Morphine interaction?

Definition
Morphine is an opioid drug used as a strong painkiller to treat severe pain by blocking pain signals from traveling along the nerves to the brain. Morphine can be used for acute pain after an operation, injury, or pain associated with diseases such as cancer or heart attack as well as for persistent pain.1

Symptoms
Morphine intake may in some cases lead to an addiction. In addition, alcohol consumption can increase the risk for the most common side effects of morphine which include:1

  • Purging
  • Sleepiness
  • Constipation
  • Confusion
  • Dizziness
  • Headache
  • Itchiness or rash

Even though morphine is suitable for both adults and children, morphine may not be given to people who have one of the following conditions, diseases, or disorders:

  • In general, not recommended during pregnancy
  • Previous allergic reaction to other medicines
  • Lung diseases
  • Diseases causing seizures
  • Head injuries
  • Untreated thyroid diseases
  • Adrenal gland diseases
  • Kidney or liver diseases
  • Enlarged prostate condition
  • Low blood pressure
  • Myasthenia gravis

Cause
Morphine is an opioid drug that works by interacting with opioid receptors in the brain, spinal cord, and other areas of the body, leading to reduced pain.2

  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC
  • CBD

Plant Cannabinoids

  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Morphine interaction & cannabinoids

Morphine Injection (1)

It was suggested that a combination of morphine with cannabinoids may exhibit a synergistic interaction effect in treating some types of pain. Low doses of both morphine and cannabinoids also decrease the risk of tolerance being developed to the drugs.3

Note: If you have any further information relevant to the connection between Morphine interaction and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

In animal models, morphine potency was found to be increased when combined with THC (Smith et al., 1998; Tham et al., 2005).

Also, it was also shown that tolerance can be avoided when combining low doses of morphine and THC (Cichewicz and McCarthy, 2003; Smith et al., 2007).

Only in the acetic acid-stimulated stretching assay, CBD was found to exhibit a synergistic effect with morphine (Neelakantan et al., 2015).

References
Clinical trials

It was shown that a combination of THC and morphine can produce some analgesic effects, but more studies are needed (Naef et al., 2003). In the affective component of pain, THC was found to exhibit a synergistic effect when combined with morphine (Roberts et al., 2006).

References

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