MDMA intoxication

MDMA, commonly known as ecstasy is a synthetic drug that causes the release of the neurotransmitters serotonin, dopamine and norepinephrine in the central nervous system, leading to arousal, alertness, focus, restlessness, and anxiety.

  • What is MDM intoxication?
  • MDMA intoxication & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is MDMA?

Definition and cause
MDMA, or 3,4-methylenedioxy-methamphetamine, commonly known as ecstasy is a synthetic drug that causes the release of the neurotransmitters serotonin., dopamine. and norepinephrine. in the central nervous system.
MDMA intake leads to arousal, alertness, focus, restlessness, and anxiety. It increases heart rate, blood pressure and triggers the release of glucose in the central nervous system. 1
MDMA intake can lead to a sense of euphoria, empathy, and enhanced sensuality.2
Acute illnesses of MDMA consumption are relatively rare, however, if complications occur, they may be fatal.

Symptoms
The main symptoms of MDMA intoxication are:1

  • Serotonin syndrome (acute confusion, excessive sweating, diarrhea, and cardiovascular instability)
  • Increased heart rhythm (100+ beats per minute)
  • Insomnia
  • Increased blood pressure
  • Dilation of pupils
  • Involuntary movements specifically eyes and jaw
  • Increased sweating
  • Dry mouth
  • Elevated mood
  • An extreme elevation of body temperature (hyperpyrexia or high fever)
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC

  • CB1
  • CB2
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between MDMA intoxication
& cannabinoids

Mdma Intoxication dopamine brain scan

Preclinical data proposes that the cannabinoid THC may be therapeutic in the treatment of MDMA intoxication as THC exhibits antioxidant and anti-inflammatory effects, whereas MDMA causes oxidative stress.4

Note: If you have any further information relevant to the connection between MDMA intoxication and cannabinoids, or find any of the information inaccurate, outdated or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

MDMA (often known as ecstasy) was shown to produce various effects including hyperthermia, oxidative stress, and neuronal damage. THC was observed to produce hypothermia as well as exhibit antioxidant and anti-inflammatory activities. In one study, mice were given MDMA (20 mg/kg x 4) and were pretreated with THC (3 mg/kg x 4) to evaluate the effect of THC. It was found that hyperthermia, glial activation, and dopaminergic terminal loss were prevented by THC (Touriño et al., 2010).

Similarly, in rhesus monkeys, MDMA-induced hyperthermia (1.78 mg/kg oral) was prevented by 0.3 mg/kg THC (intramuscular) in a CB1-dependent manner (Taffe, 2012).

In rats, hyperthermia, increased anxiety-like behavior, and reduced exploration can be the effects produced by MDMA. These behavioral effects were shown to be reduced by THC (Shen et al., 2011).

References
Clinical trials

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