MDMA (often known as ecstasy) was shown to produce various effects including hyperthermia, oxidative stress, and neuronal damage. THC was observed to produce hypothermia as well as exhibit antioxidant and anti-inflammatory activities. In one study, mice were given MDMA (20 mg/kg x 4) and were pretreated with THC (3 mg/kg x 4) to evaluate the effect of THC. It was found that hyperthermia, glial activation, and dopaminergic terminal loss were prevented by THC (Touriño et al., 2010).
Similarly, in rhesus monkeys, MDMA-induced hyperthermia (1.78 mg/kg oral) was prevented by 0.3 mg/kg THC (intramuscular) in a CB1-dependent manner (Taffe, 2012).
In rats, hyperthermia, increased anxiety-like behavior, and reduced exploration can be the effects produced by MDMA. These behavioral effects were shown to be reduced by THC (Shen et al., 2011).