Lung Cancer

Lung Cancer involves the growth of abnormal cells in one or both lungs. The abnormal cells can form tumors and  cause problems with the function of the lung which is critical for providing oxygen to the body through the blood. Statistically, lung cancer is the most deadly type of cancer worldwide

  • What is Lung Cancer?
  • Lung Cancer & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Lung Cancer?

Definition
Lung cancer involves the growth of abnormal cells in one or both lungs. Lung cancer cells contain mutations leading to uncontrollable cell division and growth. Similarly, it can spread and damage/destroy normal tissue. The abnormal cells can form tumors and cause problems with the function of the lung which is critical for providing oxygen to the body through the blood. 1 Statistically, lung cancer is the most deadly type of cancer worldwide. 2

Symptoms
Often, signs and symptoms of Lung Cancer do not appear until the disease is at an advanced stage.
The main symptoms of lung cancer may be:1

  • Lingering cough that may aggravate
  • Coughing blood event very little
  • Easily out of breath (shortness)
  • Hoarseness
  • Frequent chest infections (e.g. bronchitis and pneumonia)
  • Unexplained headaches
  • Unexpected weight loss

Cause
As other types of cancer, lung cancer involves the growth of abnormal cells containing mutations that lead to uncontrollable growth and cell division. It can spread and damage normal tissue. The main causes of lung cancer are:3

  • Smoking, both firsthand and secondhand smoke (the primary cause)
  • Exposure to radon gas and/or asbestos and other carcinogens
  • Previous radiation therapy
  • Heredity

Lung cancer can be divided into 2 types

  1. Small cell lung cancer
    Almost solely found in heavy smokers
  2. Non-small cell lung cancer
    An umbrella term for a group of lung cancers
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • CBD
  • THC
  • TRPV1
  • PPARγ

  • Terpenes
  • Strains
  • Enzymes
  • Metabolites
  • Humulene
  • Limonene

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Lung Cancer
& cannabinoids

Lung Cancer Xray

Preclinical data proposes that the THC and CBD may be therapeutic in the treatment of lung cancer.4

In a case report, it was shown that CBD may have been involved in producing positive effects in a patient with Lung Cancer. This striking response was seen after the patient self-administered CBD oil for one month. No other identifiable lifestyle, drug, or dietary changes could be found.5

In addition, a recent study proposes that the cannabinoid receptors CB1 and CB2 may play a role in the survival of patients and can serve as potential markers for patient survival.6

For more information, please refer to the general cancer entry.

Note: If you have any further information relevant to the connection between Lung Cancer and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

CBD addition (1nM-3μM) to the lung cancer cell lines (A549, H358, and H460), upregulated ICAM-1 and TIMP-1 through TRPV1. In mice carrying human lung cancer xenografts, CBD presence caused a 2.6 and 3.0 fold increase of ICAM-1 and TIMP-1 protein, suppressing lung cancer cell invasion and metastasis (Ramer et al., 2012).

In cancer cell lines (A549 and H460) and human metastatic lung cancer cells, it was shown that ICAM-mediated Lymphokine-Activated Killer cell adhesion and cancer cell lysis can be induced by CBD and THC (Haustein et al., 2014).

In lung cancer cell lines (A549, H460) and human lung cancer cells, it was found that apoptotic cell death can be induced by CBD through COX-2 and PPARγ. Furthermore, in A549-xenografted nude mice, it was shown that tumor regression can be caused by CBD (Ramer et al., 2013).

References
Clinical trials

Want to know more about Lung Cancer?

Then signup our FREE newsletter below