The endocannabinoid system is involved in neonatal Hypoxic-ischemic encephalopathy. It was shown that CB1 and CB2 are increased and AEA, 2-AG, OEA, and PEA demonstrate elevated levels after cerebral ischemia (England et al., 2015; Lara-Celador et al., 2013).
Astrocytic reaction, neuronal death, and dendritic loss can be reduced through selective activation of CB1 in a stoke model in adult mice (Caltana et al., 2015).
Neuroinflammation, ischemic injury, and cognitive deficits can be reduced through selective activation of CB2 in different models of stroke (Choi et al., 2013; Ronca et al., 2015; Zarruk et al., 2012).
In hypoxia-ischemic animal models, CBD has been demonstrated to have neuroprotective properties with functional and behavioral recovery (Alvarez et al., 2008; Lafuente et al., 2011).