Intracerebrovascular application of anandamide and 2AG may exhibit gastroprotective effects in ethanol-induced ulcers, proposing that endocannabinoids play a role in the central nervous system (Gyires and Zádori, 2016).
TRP receptors (TRPV1-4, TRPA1, TRPM8) are involved in pain sensation but may also play a role in inflammation. It was shown that there is an interaction between TRPs and cannabinoids (endo and phytocannabinoids) with varying affinities (De Petrocellis et al., 2011, 2012). This means that TRPs can be excellent targets and plant cannabinoids excellent substrates to manage pain and inflammation.
Cannabinoids like THCV, CBD, and CBG were shown to exhibit anti-inflammatory activities in experimental intestinal inflammation (Alhouayek and Muccioli, 2012).
In the TNBS mouse model of colitis, colitis was observed to be attenuated by CBD (5 mg/kg i.p. twice daily for three days). Furthermore, the same cannabinoid was found to promote endothelial, and epithelial wound healing (Krohn et al., 2016).