In a study with mice, it was shown that the levels of endocannabinoid AEA and suspected endocannabinoid PEA were elevated and TRPV1 and PPARα were upregulated (Petrosino et al., 2010). PEA is involved in enhancing the effect of AEA at CB1, CB2, and TRPV1 receptors and shielding against keratinocyte inflammation in a TRPV1-, but not CB1, CB2, or PPARα-dependent way.
In mice with Oxazolone-Induced Contact Dermatitis, it was found that the level of 2-AG was elevated, and inflammation was inhibited via CB2 receptors (Oka et al., 2006).
In another study with mice, it was shown that inflammation in allergic contact dermatitis was inhibited by CB1 and CB2 (Karsak et al., 2007).
Skin inflammation can be inhibited by THC topical application but in a CB1- and CB2-independent way (Gaffal et al., 2013).