Cervical Cancer

Cervical Cancer is a type of cancer found in women. It takes places in the cells of the cervix. The primary cause of cervical cancer is the sexually transmitted human papillomavirus (HPV) though the infection may be caused by environmental factors too.

  • What is Cervical Cancer?
  • Cervical Cancer & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Cervical Cancer?

Definition
Cervical Cancer is a type of cancer found in women. It takes place in the cells of the cervix. The primary cause of cervical cancer is the sexually transmitted human papillomavirus (HPV) though the infection may be caused by environmental factors too.1

Symptoms
Signs and symptoms of Cervical Cancer usually do not appear before an advanced stage, meaning that when symptoms do appear, they must be taken very seriously. Signs and symptoms of more-advanced cervical cancer are:1

  • Bleeding from the vagina after intercourse, menopause, or between periods
  • Pelvic pain
  • Pain during intercourse
  • Bloody, watery discharge from the vagina that may have a heavy an unpleasant smell

Cause
As other types of cancer, Cervical Cancer involves the growth of abnormal cells that contain mutations leading to uncontrollable cell division and growth. Similarly, it can spread and damage/destroy normal tissue.
Up to this date, the exact cause of cervical cancer is not yet known. However, it is known that HPV is involved in the development of cervical cancer. Furthermore, HPV is prevalent among women and many of them who have the virus do not develop Cervical Cancer, suggesting that other factors may play a role in the development of this cancer, including environmental and lifestyle choices. Please refer to the general cancer entry for more information.1

There are 2 types of cervical cancer

  • Squamous cell carcinoma
    This type of cervical cancer starts in the thin and fat cells
  • Adenocarcinoma
    This type of cervical cancer starts in the column-shaped glandular cells

Risk factors of cervical cancer

  • Unprotected sex with numerous partners
  • Early sexual activity
  • Other sexually transmitted infections
  • Exposure to smoke (squamous cell carcinoma)
  • Unbalanced/weakened immune system
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC
  • CBD

  • CB1
  • CB2
  • TRPV1

  • Anandamide
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Cervical Cancer
& cannabinoids

Cervical Cancer Woman Graphic Uterus

Preclinical evidence proposes that the cannabinoid THC may be therapeutic in the treatment of Cervical Cancer as cancer cells express cannabinoid receptors.2
In addition, it has been shown that cell growth can be suppressed by the cannabinoid CBD rather than Cannabis sativa extracts in cervical cancer cell lines. Also, cell death was shown to be induced by CBD rather than Cannabis sativa extracts.3

Note: If you have any further information relevant to the connection between Cervical Cancer and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

The cervix express cannabinoid receptors such as CB1, CB2, and TRPV1, and those receptors are involved in the multiple biological effects of Anandamide (Ayakannu et al., 2015).

Overexpression of TIMP-1 accounts for the anti-invasive and apoptotic functions on cancer cells from Anandamide (and THC) (Ramer and Hinz, 2008).

More research is needed to elucidate the specific mechanism of the endocannabinoid system. Some studies propose that TRPV1 and not CB1 or CB2 is responsible for Anandamide anticancer properties (Contassot et al., 2004; Ramer and Hinz, 2008).

References
Clinical trials

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