The ECS is comprised of:
• Cannabinoid receptors – found on the surface of cells
• Endocannabinoids – small molecules that activate cannabinoid receptors
• Metabolic enzymes – that break down endocannabinoids
are located on the surface of cells in your body and they “listen” to conditions outside the cell. They transmit information about altered conditions to the inside of the cell and initiate the relevant cellular response.
There are two main cannabinoid receptors: CB1 and CB2. These are not the only cannabinoid receptors, but the first to be discovered and remain the best studied.
CB1 and CB2 receptors are key players in the ECS. CB1 receptors are more prevalent in the central nervous system, including neurons in the brain. In contrast, CB2 receptors are more abundant outside the nervous system, including cells of the immune system.
such as ANA and 2-AG are the best-studied molecules, that help regulate and balance many processes in the body.
Distance running or other exercises that require stamina can lead to a feeling known as “runners high”, which is linked to decreased anxiety and pain, an increased sense of relaxation, and a feeling of euphoria. The levels of Anandamide and β-endorphin are found to be abundantly increased in the plasma of humans and mice after long-distance running.
include FAAH and MAGL that are responsible for the degradation of endocannabinoids. FAAH is responsible for breaking down ANA and MAGL is responsible for breaking down 2-AG.
These enzymes ensure that endocannabinoids are present when needed, but no longer than necessary. This process separates endocannabinoids from many other molecular signals in your body, such as hormones or classic neurotransmitters, which can persist for many seconds or minutes, or be packed and stored for later use.
The ECS plays a role in many critical functions of our body such as energy supply, brain activity, cell division, and immunity to maintain our bodies’ structural and functional integrity.
If the ECS fails to work properly the interactions and communication between the different organs and body activities will be interrupted which can cause diseases, such as
The ECS maintains balance or homeostasis in our body, but it is also a system evolved from nature working as a biochemical neurological system.
The cannabis plant contains cannabinoids that can be used to regulate our ECS and connected systems. This offers some great opportunities in therapeutics treatment as plant cannabinoids can be used to enhance and optimize our endocannabinoid system, and thus anticipate, prevent, or even help fight diseases.
The acting of the body’s cannabinoids – is similar to Phytocannabinoids, produced by the cannabis plant. However, if the ECS becomes unbalanced, this may lead to stress, bad sleep, or the development of diseases.
Addition of natural and plant-based cannabinoids to our diet, can improve the functions of the ECS and enhance the power our body has to heal itself.