Patients with anorexia have elevated levels of CB1 receptors in brains. Similarly, bulimia patients were also shown to have elevated levels of CB1 receptors in some brain regions (Gérard et al., 2011).
It was demonstrated that mutations in CB1 and FAAH (the major endocannabinoid degrading enzyme) are connected to anorexia and bulimia (Monteleone et al., 2009).
The pancreas and tissues of the gastrointestinal tract express G protein-coupled receptor 119 (GPR119). GPR119 plays a role in food intake and glucose homeostasis (maintaining blood glucose level at a normal limit). GPR119 can interact with endocannabinoids such as anandamide, 2OG, PEA, and OEA.
Out of endogenous activators, it was shown that the endocannabinoid OEA exhibits the strongest effect on GPR119 and reduces food intake and weight gain via PPARα and TRPV1 (Overton et al., 2006).