Bulimia

Bulimia nervosa is a phsycological eating disorder. It involves a cycle of binge-eating followed by excessive weight control methods. Bulimia causes a distorted and negative body image that can interfere with most aspects of life.

  • What is Bulimia?
  • Bulimia & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Bulimia?

Definition
Bulimia nervosa (commonly referred to just as bulimia) is a mental eating disorder. It involves a cycle of binge-eating followed by excessive weight control methods such as purging, meaning that people will try to get rid of their calories in an unhealthy way. Bulimia causes a distorted and negative body image that can interfere with most aspects of life.1

Symptoms
The majority of people who suffer from bulimia have a normal weight or slightly overweight, therefore, the signs and symptoms of bulimia may be difficult to detect.1
However, the main symptoms may be:

  • Refusion of eating in public or among others
  • Persistent worrying or complaining of becoming/being overweight
  • Strict dieting or repeatedly eating unusually large meals
  • The strong correlation between eating and frequent/long use of the bathroom, possibly caused by forced vomiting or the use of laxatives
  • Extensive exercising
  • Swelling in the face, hands, and feet
  • Unusually many sores, scars, or calluses on the hands or knuckles
  • Damaged teeth and gums

Cause
Up to this date, the exact cause of bulimia is not yet known. However, factors that may play a role in the development of the eating disorder are:1

  • Close family history of eating disorders
  • Being overweight as a child or teen
  • Phycological and emotional problems e.g. depression, anxiety, a traumatic event, low self-esteem, or stress
  • Dieting
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC
  • THCV

  • CB1
  • GPR119
  • TRPV1
  • PPARα

  • OEA
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

  • FAAH

Metabolites

The connection between Bulimia
& cannabinoids

Bulimia Weight Scale Feet

It is known that eating behavior can strongly be affected by cannabinoids and endocannabinoids. THC can stimulate appetite and THCV can inhibit it. However, more studies are needed to examine how cannabinoids can be used to fight bulimia.2

Note: If you have any further information relevant to the connection between Bulimia and cannabinoids, or find any of the information inaccurate, outdated or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

Patients with anorexia have elevated levels of CB1 receptors in brains. Similarly, bulimia patients were also shown to have elevated levels of CB1 receptors in some brain regions (Gérard et al., 2011).

It was demonstrated that mutations in CB1 and FAAH (the major endocannabinoid degrading enzyme) are connected to anorexia and bulimia (Monteleone et al., 2009).

The pancreas and tissues of the gastrointestinal tract express G protein-coupled receptor 119 (GPR119). GPR119 plays a role in food intake and glucose homeostasis (maintaining blood glucose level at a normal limit). GPR119 can interact with endocannabinoids such as anandamide, 2OG, PEA, and OEA.

Out of endogenous activators, it was shown that the endocannabinoid OEA exhibits the strongest effect on GPR119 and reduces food intake and weight gain via PPARα and TRPV1 (Overton et al., 2006).

References

 

Clinical trials

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