Breast cancer

Breast cancer is a type of cancer that takes place in the cells of the breasts. It is primarily found in women due to larger amount of breast tissue.

  • What is Breast Cancer?
  • Breast Cancer & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Breast Cancer?

Definition
Breast cancer is a type of cancer that takes place in the cells of the breasts. It is primarily found in women due to a larger amount of breast tissue.1

Symptoms
The main signs and symptoms of breast cancer may be:1

  • Change in shape, size, and form of a breast
  • A lump in the breast (a part of the breast that feel different compared to surrounding tissue)
  • Dimpling or other changes to the skin over the breast
  • Recently inverted nipple
  • Scaling of the pigmented skin area surrounding the nipple

Cause
As other types of cancer, breast cancer involves the growth of abnormal cells that contain mutations leading to uncontrollable cell division and growth. Similarly, it can spread and damage/destroy normal tissue. However, in breast cancer, the disease usually develops with cells in the milk-producing ducts known as invasive ductal carcinoma or in the glandular tissue known as invasive lobular carcinoma.1

The main risk factors for developing breast cancer may be but are not limited to:

  • Heredity and genetics
  • The female sex
  • Personal history of other breast diseases
  • Radiation exposure
  • Obesity
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • CBD
  • THC

  • CB1
  • CB2
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

  • Eugenol
  • Humulene

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Breast Cancer
& cannabinoids

Breast Cancer Woman Nude Bow

Preclinical evidence proposes that the cannabinoids CBD and THC may be therapeutic in the treatment of breast cancer, as cannabinoids may exhibit anti-breast cancer activities.
CBD could be combined with the anticancer drug Paclitaxel to inhibit neuropathic pain and boost the effect of this drug.2
In addition, it was observed that autophagy-mediated apoptotic death of tumor cells can be stimulated upon treatment with cannabinoids.3

Please refer to our general cancer entry for more information.

Note: If you have any further information relevant to the connection between Breast Cancer and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical rrials
Review

Several studies showed that THC and CBD exhibit anti-cancer activity through CB1 and CB2 receptors (Caffarel et al., 2008; Massi et al., 2013).

CBD can help in suppressing cancer cell growth and proliferation through autophagy process without affecting non-cancer cells (Elbaz et al., 2015; Shrivastava et al., 2011).

It was shown that CBD can help in inhibiting the expression of ID1 protein in advanced stages of breast cancer metastasis (Murase et al., 2014). Furthermore, it was found that CBD can help in suppressing paclitaxel-induced neuropathic pain through 5HT1A (Ward et al., 2014).


References

 

Clinical trials

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