Bone cancer

Bone cancer is a rare type of cancer. It can take place in any bone in the body. Three types of bone cancer exist: osteosarcoma, chondrosarcoma and ewing sarcoma.

  • What is Bone Cancer?
  • Bone Cancer & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Bone Cancer?

Definition
Bone cancer is a rare type of cancer. It can take place in any bone in the body. Three types of bone cancer exist: osteosarcoma, chondrosarcoma, and ewing sarcoma.1

Symptoms1

  • Pain in bone
  • Unexpected fractures in bone (weakness)
  • Fatigue
  • Unintended and unexplained weight loss

Cause
The type of bone cancer depends on the type of cell where the cancer started. The most common types of bone cancer are:1

  • Osteosarcoma
    The most common type of cancer and is primarily found in children and young adults. Cancer starts in cells responsible for producing bones.
  • Chondrosarcoma
    Cancer cells are involved in producing cartilage. Chondrosarcoma usually occurs in the pelvis, legs, and arms of older adults
  • Ewin sarcoma
    Cancer develops in the pelvis, legs, or arms of children and young adults

It is not fully understood what causes bone cancer. However, factors that can increase the risk of developing bone cancer are:1

  • Heredity
  • Rare genetic syndrome e.g. Li-Fraumeni and retinoblastoma
  • Paget’s disease of bone
  • Radiation therapy for cancer
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC

  • CB1
  • CB2
  • TRPV1

  • Anandamide
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Bone Cancer
& cannabinoids

Bone Cancer xray

In in vivo and in vitro studies, cannabinoids were found to suppress tumor growth and metastases as well as trigger apoptosis in bone cancer.3
In addition, preclinical evidence proposes that the cannabinoid THC may be beneficial in the treatment of bone cancer as cannabinoids may have anti-cancer and anti-inflammatory effects.3

Please refer to our general cancer entry for more information.

Note: If you have any further information relevant to the connection between Bone Cancer and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

Research indicates that CB1, CB2, and TRPV1 receptors can be expressed by bone cancer cells.

The inflammatory process of bone cancer cells can be affected by CB2 agonists such as Anandamide or THC through modulation of interleukin, tumor necrosis factor α and nuclear factor-κB expression, and cofilin-1 protein (Hsu et al., 2007; Lu et al., 2015; Yang et al., 2015). This inflammatory process plays a role in pain regulation and cell death via apoptosis. TRPV1 and CB1 receptors play a role in regulating cancer pain (Kawamata et al., 2010).

References
Clinical trials

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