Bladder cancer

Bladder cancer is a common type of cancer. It often occurs in the urothelial cells that line the inside of the bladder. However, as urothelial cells are also present in the kidneys and ureters, bladder cancer may occur there as well.

  • What is Bladder Cancer?
  • Bladder Cancer & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Bladder Cancer?

Definition
Bladder cancer is a common type of cancer. It often occurs in the urothelial cells that line the inside of the bladder. However, as urothelial cells are also present in the kidneys and ureters., bladder cancer may occur there as well. It is easily treatable if diagnosed at an early stage, though, like other types of cancer, it may reoccur.1

Symptoms
The signs and symptoms of cancer may be but  not limited to:1

  • Frequent and/or painful urination
  • Back pain
  • Blood in urine

Cause
As other types of cancer, bladder cancer involves the growth of abnormal cells which contain mutations leading to uncontrollable cell division and growth. Similarly, it can spread and damage/destroy normal tissue.1

Risk factors may be:

  • Smoking or exposure to smoking
  • Age, commonly diagnosed after the age of 55
  • The sex, men are more likely to develop the cancer
  • Exposure to specific chemicals
  • Previous cancer treatment
  • Chronic bladder inflammation (cystitis)
  • Heredity
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • CBD
  • THC

  • CB1
  • CB2
  • GPR55

  • 2AG
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

Terpenes

Strains

Synthesizing & Degrading Enzymes

Metabolites

The connection between Bladder Cancer
& cannabinoids

Bladder Cancer Xray

It is suggested that cannabinoids exhibit anti-metastatic activities. However, further studies are needed to examine the effect of CB2 agonists in the treatment of bladder cancer.2

Note: If you have any further information relevant to the connection between Bladder Cancer and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion & clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

The potential treatment of cannabinoids in bladder cancer is currently being studied by several research groups.

To this date, it is known that cannabinoid receptors such as CB1, CB2, and GPR55 are expressed by human bladder cells (Bakali et al., 2014).

It was shown that human bladder cancer (BC) cells RT4 and RT112 have increased expression of CB2 receptors. Cytotoxicity in bladder cancer cell lines and changes in cellular sphingolipids metabolism can be induced via activation of CB2 with the synthetic cannabinoid agonist JWH015 (Bettiga et al., 2017).

2AG plays a role in controlling inflammation and proliferation processes of bladder carcinoma cells, probably through CB receptors (Gasperi et al., 2014).

References
Clinical trials

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