Autism

Autism spectrum disorder is a group of neurodevelopment disorders that affect how a person socializes and perceives the world.

  • What is Autism?
  • Autism & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Autism?

Definition
Autism spectrum disorder is a group of neurodevelopment disorders that affect how a person socializes and perceives the world. People with autism spectrum disorder often have limited and repetitive patterns of behavior compared to people who do not have this condition.1
Autism spectrum disorders are often noticeable and diagnosed in childhood, and boys have a higher risk to develop an autism spectrum disorder compared to girls.2

Symptoms may be:1

  • Difficulty in social interactions and communication as a person within the autism spectrum is unable to relate and understand others to the same extent
  • Limited and/or repetitive patterns of behavior
  • Highly engaged in special interests or activities
  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC

  • CB1
  • CB2
  • GPR55
  • PPARα
  • PPARγ

  • Anandamide
  • OEA
  • PEA
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites

  • FAAH

The connection between Autism
& cannabinoids

Autism brain scan dots

There is evidence showing that the endocannabinoid system may be involved in the development of autism spectrum disorders, therefore, treatment with cannabinoids may be beneficial.3

However, there is a lack of evidence for cannabis use in autism spectrum disorders, indicating that large-scale controlled trials are needed to better understand risks and benefits.4

Note: If you have any further information relevant to the connection between Autism and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials
Review

In a genetic mouse model of mental retardation and autism (FMR1 knockout), cognitive defects were normalized through blockage of CB1 (Busquets-Garcia et al., 2013), proposing that CB1 may be a therapeutic target in the treatment of autism.

In an observational study, it was demonstrated that CBD-enriched Cannabis sativa extract can exhibit positive effects in multiple autistic symptoms without producing the typical side effects found in patients who receive ASD medications (Fleury-Teixeira et al., 2019).

References
Fleury-Teixeira, Paulo, et al. “Effects of CBD-enriched Cannabis sativa extract on autism spectrum disorder symptoms: an observational study of 18 participants undergoing compassionate use.” Frontiers in neurology 10 (2019): 1145.

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