Acute Liver Failure

Acute liver failure is loss of liver function that takes place over the period of days or weeks. If untreated, the condition can be fatal.

  • What is Acute Liver Failure?
  • Acute Liver Failure & cannabinoids
  • Text references, literature discussion
    & clinical trials

What is Acute Liver Failure?

Acute liver failure or fulminant hepatic failure is a loss of liver function that takes place over a period of days or weeks. If untreated, the condition can be fatal.
Sometimes the condition can be reversed with medical treatment though in some cases, a liver transplant may be needed.1

As the condition is acute, any sudden and extraordinary changes in mental state, personality, behavior, or if any of the following symptoms occur, medical attention must be provided immediately:1

  • Acute yellowing of skin and eyeballs (jaundice)
  • Soreness in the upper abdomen

Other symptoms may be:

  • Abdominal swelling
  • Nausea and purging
  • Disorientation and confusion
  • Tiredness/sleepiness
  • A general sense of unpleasantness

Acute Liver Failure symptoms must be taken very seriously due to serious complications such as excessive bleeding and increased pressure in the brain.1

Acute liver failure can be caused by several risk factors that may be both external, involving the consumption of toxins and herbal supplements, and internal involving hepatitis, other viruses, and underlying diseases. However, the most common cause of Acute Liver Failure is an overdose of over-the-counter (OTC) pain relievers and prescription drugs.1

  • Cannabinoids
  • Cannabinoid receptors
  • Endocannabinoids

  • THC
  • CBD

  • CB1
  • CB2
  • 5-HT1a
  • TRPV 1

  • 2AG
  • Terpenes
  • Strains
  • Enzymes
  • Metabolites



Synthesizing & Degrading Enzymes


The connection between Acute Liver Failure
& cannabinoids

Acute Liver Failure

Preclinical studies proposed that CBD is involved in restoring liver function, normalizing 5-HT levels. and improving brain pathology with normalization of brain function. 2

Preclinical data also proposes that THC and CBD may have therapeutic potential when treating acute liver failure. 3

Note: If you have any further information relevant to the connection between Acute Liver Failure and cannabinoids, or find any of the information inaccurate, outdated, or incomplete please contact us here.

Text references, literature discussion
& clinical trials

  • Text references
  • Literature discussion
  • Clinical trials

In a mouse model of hepatic encephalopathy, it was shown that acute liver failure is induced by thioacetamide. Also, increased brain 5-HT levels and severe impairment of cognitive function are caused by thioacetamide. Cognitive function, brain 5-HT levels, and liver function can be restored by 5mg/kg of CBD (Avraham et al., 2011).

AMP kinase, which is normally under the control of CB1 regulates cerebral intracellular energy levels. In liver failure/hepatic encephalopathy, AMP kinase/energy levels are maintained through upregulation of CB2 (Dagon et al., 2007).

In acute liver failure induced by galactosamine/lipopolysaccharide, CB2 stimulation demonstrated a protective/anti-inflammatory effect. This is through M1 to M2 shift in macrophages (Tomar et al., 2015).

Clinical trials

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